Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience.
نویسندگان
چکیده
Photoacoustic imaging has evolved into a clinically translatable platform with the potential to complement existing imaging techniques for the management of cancer, including detection, characterization, prognosis, and treatment monitoring. In photoacoustic imaging, tissue is optically excited to produce ultrasonographic images that represent a spatial map of optical absorption of endogenous constituents such as hemoglobin, fat, melanin, and water or exogenous contrast agents such as dyes and nanoparticles. It can therefore provide functional and molecular information that allows noninvasive soft-tissue characterization. Photoacoustic imaging has matured over the years and is currently being translated into the clinic with various clinical studies underway. In this review, the current state of photoacoustic imaging is presented, including techniques and instrumentation, followed by a discussion of potential clinical applications of this technique for the detection and management of cancer. (©) RSNA, 2016.
منابع مشابه
Application Brief: Tumor Microenvironment Imaging with Photoacoustic Technology
Pharmaceutical development of therapeutic and imaging agents that improve tumor prognosis is an expensive R&D effort with many compounds in the preclinical testing pipeline (Olafsson et al., 2010). Introducing an efficient way to screen and reject unpromising compounds during the discovery research phase of development, such as in vivo preclinical imaging, could save some of the $800 million in...
متن کاملB-Mode Photoacoustic Imaging using Linear Array: Numerical Study for Forward-Backward Minimum Variance Beamformer Combined with Delay-Multiply-and-Sum
Photoacoustic imaging (PAI) is a promising medical imaging modality which provides the resolution of Ultrasound (US) and the contrast of Optical imaging modalities. One of the most important challenges in PAI is image formation, especially in the case that a linear-array US transducer is used for data acquisition. This is due to the fact that in the linear-array scenario, there is only 60 degre...
متن کاملPhotoacoustic imaging in biomedicine
Photoacoustic imaging also called optoacoustic or thermoacoustic imaging has the potential to image animal or human organs, such as the breast and the brain, with simultaneous high contrast and high spatial resolution. This article provides an overview of the rapidly expanding field of photoacoustic imaging for biomedical applications. Imaging techniques, including depth profiling in layered me...
متن کاملProgrammable Real-time Clinical Photoacoustic and Ultrasound Imaging System
Photoacoustic imaging has attracted interest for its capacity to capture functional spectral information with high spatial and temporal resolution in biological tissues. Several photoacoustic imaging systems have been commercialized recently, but they are variously limited by non-clinically relevant designs, immobility, single anatomical utility (e.g., breast only), or non-programmable interfac...
متن کاملIn vivo 3-dimensional photoacoustic imaging of the renal vasculature in preclinical rodent models.
Non-invasive imaging of the kidney vasculature in preclinical murine models is important for studying renal development, diseases and evaluating new therapies, but is challenging to achieve using existing imaging modalities. Photoacoustic imaging is a promising new technique that is particularly well suited to visualising the vasculature and could provide an alternative to existing preclinical ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Radiology
دوره 280 2 شماره
صفحات -
تاریخ انتشار 2016